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:: year 1, Issue 1 (Journal of Acoustical Engineering Society of Iran 2014) ::
مجله علمی پژوهشی انجمن مهندسی صوتیات ایران 2014, 1(1): 43-50 Back to browse issues page
Effect of doxorubicin and dual frequency (kHz-MHz) ultrasound waves exposure on the adenocarcinoma tumor growth
Homa Soleimani, Parviz Abdolmaleki *, Tayebe Toliyat, Manije Mokhtari-Dizaji, Abbas Tavasoli
Abstract:   (8575 Views)
The effect of dual-frequency low-intensity ultrasound waves with repeated radiation on the breast tumor of Balb/c mice was investigated in the presence of a chemotherapy drug. In this study, the tumor-bearing mice were divided into five groups, two untreated groups (control and sham) and three experimental groups. Experimental groups were: a dual-frequency ultrasound (US) radiation (1 MHz and 150 kHz), a dual-frequency ultrasound with triple exposure (3 x 30 min), and one treated with a dose of doxorubicin alone. The results clearly demonstrate the significant effect of triple exposures of dual-frequency US [dual (REP)] on the increase of survival period of the studied mice. The dual (REP) group, with results similar to the drug-treated group, shows a significant difference from the sham group. With the repeated exposure of dual-frequency ultrasound radiation on mice carrying the chemotherapy drug, the T2 and T5 times (times needed by the tumor to grow to 2 and 5 times its initial volume, respectively) decrease. This decrease in T5 time is significant. It seems that repeated simultaneous exposure to low-intensity dual-frequency (1 MHz and 150 kHz) US can retard the growth of the adenocarcinoma tumor and increase the survival period in mice.
Keywords: Repetition Exposure, Ultrasound waves, Doxorubicin, Adenocarcinoma tumor, Balb/c
Full-Text [PDF 674 kb]   (638 Downloads)    
Type of Study: Research | Subject: Hydroacoustics
Received: 2013/10/22 | Accepted: 2014/01/24 | Published: 2014/03/19
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Soleimani H, Abdolmaleki P, Toliyat T, Mokhtari-Dizaji M, Tavasoli A. Effect of doxorubicin and dual frequency (kHz-MHz) ultrasound waves exposure on the adenocarcinoma tumor growth. مجله علمی پژوهشی انجمن مهندسی صوتیات ایران. 2014; 1 (1) :43-50
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year 1, Issue 1 (Journal of Acoustical Engineering Society of Iran 2014) Back to browse issues page
مجله علمی-پژوهشی انجمن مهندسی صوتیات ایران Journal of Acoustical Engineering Society of Iran
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